Oral alitretinoin is indicated for use in adults who have severe chronic hand eczema that is unresponsive to treatment with potent topical corticosteroids. The following guidance by NICE gives an overview of the usage of Alitretinoin in chronic hand eczema along with its indications. Alitretinoin is a derivative of retinoic acid (9-cis-retinoic acid) that binds to and activates intracellular retinoid receptors. These receptors regulate cellular differentiation and proliferation.The recommended dosage of Alitretinoin is 30 mg once daily for 12–24 weeks.
The dosage can be reduced to 10 mg once daily if there are unacceptable adverse effects. The recommendations are as listed below: 1. Alitretinoin is recommended, within its licensed indication, as a treatment option for adults with severe chronic hand eczema that has not responded to potent topical corticosteroids if the person has:…
