A multicenter randomized clinical trial published in JAMA Internal Medicine evaluated whether autonomous oxygen titration could improve oxygen saturation control in hospitalized adults receiving supplemental oxygen. Study Design Design: Multicenter, unblinded, parallel-group randomized clinical trial. Setting and period: Four US hospitals, May 6, 2024, to November 17, 2025. Participants: 300 adults hospitalized with acute respiratory illness, trauma, burns, or conditions requiring acute care surgery.

Intervention: Autonomous oxygen titration (152 patients) versus clinician-directed manual titration (148 patients) over the first 72 hours after randomization. Primary outcome: Proportion of time with peripheral oxygen saturation (SpO₂) of 90% to 96%. Key secondary outcome: Proportion of time with SpO₂ below 88%. Key Findings Normoxemia: Patients receiving autonomous titration spent 85% of…