Infective endocarditis may remain microbiologically unconfirmed despite clinical and echocardiographic findings supporting the diagnosis. When routine blood cultures remain negative, particularly in the absence of prior antibiotic exposure, investigating fastidious or nonculturable pathogens can help establish the etiology. (Scroll down to answer the question) Reference: Journal of the American Heart Association ##Disclaimer## The content provided on Docplexus is intended for educational purposes only.

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