Optic nerve is characterized by decreased number of nerve axons it can present as unilaterally or bilaterally may present as an isolated manifestation associated with Midline brain structural defect Such as septum pellucidum absence Agenesis of corpus callosum Cerebral hemisphere abnormality or pituitary gland abnormality Septo optic dysplasia It was first described by Briere in 1877 optic nerve hypoplasia was identified in 12 percent of blind infants in his country in Texas in 1980 incidence is 7.1 in 100 000 in Sweden, 10.9 per 100 000 in England disorder is due to genetic mutation. Risk factors are: Young maternal age Promarity Maternal Use of recreational drugs like antidepressants, anticonvulsants, antiviral agents fetal alcohol syndrome.
Differential diagnosis: Congenital coloboma of disc MG disc syndrome Tilted d syndrome Peripapillary staphyloma Glaucoma Share your opinion.
