Di-dimer is a fibrin degradation product, a small protein present in the blood after a blood clot(thrombus)formation and degradation fibrinolysis by plasmin. Its two d fragments of fibrin proteins joined by cross-link. Its first described in1970 and become a clinically useful test in1990 with sensitivity around 95%and normal value.5mgs/liters. False positivity noted in liver diseases, high rheumatoid factor, malignancies, trauma, and recent surgery. Four times increment observed with critically ill patients of SARS COVID 19.
Increased levels indicate activation of coagulation and following fibrinolytic processes, demanding diagnostic and therapeutic approaches. Di -dimer level increased in cases of 1.Deep vein thrombosis 2. Pulmonary embolism 3. Disseminated intravascular coagulation. Even before COVID 19 pandemic, increased levels of di dimer observed in cases of influenza-like…
