In 1923 Frederick Grant Banting and John James Rickard Macleod were awarded Nobel Prize for discovery of insulin and since then insulin has played a vital role in management of all types of diabetes. In this article I would like to review types of insulin and their role in the management of diabetes. I am not going to talk about all the types of insulin since the purpose of writing this article is to discuss physiology of insulin which is very important to understand and certainly helps in the patient care.
The very first insulin introduced in the market was human insulin, i.e NPH (Neutral Protamine Hagedorn) and Regular insulin. One of the issues with human insulin is human insulin don’t mimic the normal physiological endogenous basal and post prandial insulin release. As mentioned before the structure of insulin was discovered in 1920s and later it was found that by modifying the…
