Magnesium and Hormonal Balance: Expanding Clinical Relevance Magnesium deficiency is increasingly recognized as more than a nutritional concern, with growing evidence highlighting its role as a key modulator in endocrine function. This review explores how magnesium influences hormone secretion, cellular signaling, and overall metabolic homeostasis across multiple organ systems. Current evidence demonstrates its involvement in critical pathways including glucose metabolism, bone health, thyroid regulation, reproductive function, and hypothalamic–pituitary–adrenal axis activity.
Clinical associations link low magnesium levels with conditions such as diabetes, osteoporosis, and cardiometabolic disorders , underscoring its systemic impact. Despite strong observational data, gaps remain in standardized diagnostic approaches and interventional evidence. The findings emphasize the need to…
