In women with isolated polyhydramnios —a condition known for increased postpartum hemorrhage (PPH) risk—a single dose of carbetocin demonstrated superior efficacy over traditional oxytocin and oxytocin–ergometrine regimens . In this retrospective study of 286 term pregnancies , carbetocin not only minimized hemoglobin drop and blood loss but also maintained a more stable postpartum shock index , with f ewer secondary interventions required. Its long-acting uterotonic effect ensured sustained uterine contraction, offering a compelling case for its preferential use in high-risk, overdistended uterine conditions. To read more; Click here Could carbetocin become the new gold standard for PPH prevention in high-risk obstetrics?
##Reference## Elmas B, Zorlu U, Ergün GT, et al. One dose, big impact: Revisiting carbetocin in high-risk polyhydramnios deliveries. Int J Gynecol Obstet. 2025##
