Sepsis is a life-threatening condition due to excessive immune responses to infection that damages the patient's own tissues and organs. In septic shock, the severest stage of sepsis, the blood pressure drops to a dangerously low level, often leading to multiple organ failure and death. To date, there is no effective therapy yet available for septic shock. Recent findings may be a breakthrough in developing a silver bullet for the treatment of septic shock or endotoxic shock.
Orexin also called hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. The most common form of narcolepsy, in which the sufferer briefly loses muscle tone (cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells that produce it. It is used as nasal spray.antagonist to orexin developed and used as sleeping pills and antidepressants. A study in Japan found…
