Background A breakthrough infection is an infection that occurs after 14 days or more post-vaccination. 1 Breakthrough infections from SARS-CoV-2 in vaccinated people are the current focus of discussion and research in the medical fraternity worldwide. These infections are of particular significance in determining the need for a booster vaccine dose. Additionally, they form the basis for formulating the booster vaccines.
2 Assessing breakthrough COVID-19 infections The vital disease parameters include timing, frequency, causes, severity, and the level of infectiousness. If the breakthrough infections are rampant, a vaccine booster dose or modified vaccine is required. Retrospective case-control studies and closely monitored cohort studies on healthcare workers have proven reliable and effective in evaluating breakthrough COVID-19 infections. 3 Assessing COVID-19 vaccine efficacy…
