A 29-month-old infant presented with chronic influenza B infection. He had developed the infection at the age of 6 months ago, following a failed mismatched unrelated donor cord hemopoietic bone marrow transplant. Treatment with oseltamivir, zanamivir, and nitazoxanide was unsuccessful in clearing the infection, although the virus tested negative for neuraminidase resistance.
Following this, the patient underwent a second mismatched unrelated donor transplant at the age of 29 months. Which treatment interventions would you recommend for this patient? Source – Infectious Disease Society of America
