•First Generation Streptokinase Urokinase •Second Generation Alteplase (t-PA) •Third Generation Reteplase - Commenly Used Tenecteplase – Commenly Used Other: Lanoteplase(nPA), Saruplase is prourokinase (scuPA), HTUPA (human tissue urokinase type plasminogen activator) History: •In 1979, Belgian biochemist, Dr Desire Collen received a line of aggressive melanoma cells derived from a patient named Bowes. These melanoma cells showed an unusual amount of fibrinolytic activity, and Collen and colleagues worked to purify the fibrin-digesting agent. Within the year, he demonstrated that the agent was t-PA.
•It turned out that the Bowes cell line produced 100 to 1000 times more t-PA than any other known source at the time. He began…
