Ursodeoxycholic acid is 7 beta epimer of chenodeoxycholic acid which is secondry bile acid presents normally in bile, composition bile is 97%water, 7% bile salts, 2% bilirubin, 5%fat (cholestrol,fatty acids and lecithion) and 200meq/l inorganic substances.bile act as a surfactant, helping emulsification of lipids in food to form micelles. Primary bile acids are synthesized in liver and secondry bile acids forms by bacterial action in colon,main primary bile acids are 4, these are Taurocholic acid Glycocholic acid Taurochenodeoxycholic acid Glycodeoxycholic acid All are in equal in concentration, these are conjugated with with glycene and taurine then conjugated bile acid are called bile salts.
Secondry bile acids converted in colon from cholic acid to deoxycholic acid and chenodeoxucholic acid to lithocholic acid then reabsorb to maitain entero hepatic circulation but conjugated…
