AD researchers published a salient point in Neurology journal that 42% of early Alzheimer's disease patients show subclinical epileptic spikes suggesting a role of network hyperexcitability as a modifiable risk factor in the progression of AD patients. They found that low dose levetiracetam aimed at reducing epileptiform activity can improve functioning, though the sample size was small.
Network theory of nodes and edges now becoming a backbone in explaining the distant effects of a pathology in the brain.This observation is remarkable and highlights the need of doing a surface EEG in all patients with preclinical AD and MCI. How it changed your nihilism towards AD?
