Solve exciting clinical cases specific to your field of interest via Docplexus` clinical case challenge . In today's ‘Nephrology Case Challenge’ , join your fellow doctors to discuss and answer an interesting quiz. A 30-year-old man undergoes treatment for osteosarcoma with high-dose methotrexate (12 g/m 2 ) infused over four hours. Twelve hours post-infusion, he noted decreased urine output, and his creatinine rose from 0.9 mg/dL to 2.1 mg/dL.
He is initially treated with IV 0.9% saline (200 mL/h), but his urine output does not improve, and his creatinine rises to 2.7 mg/dL on day two of hospitalization. You are consulted regarding his renal failure and the persistently high levels of methotrexate. Reference: Nephrology MCQs Synap
