* Amlodipine as immuno modulator* or the current buzz word *anti PD-L1* - Start of apoptosis or programmed death is with efflux of ca++ ion from the mitochondria. If one can recollect * Robbins principles of pathology*  - So logically we can target ca ++ channels stabilizers for this purpose  - Amlodipine is known to be *anti apoptotic or programmed death inhibitor* - the reason it causes him hypertrophy albeit low incidence is also due to inhibition of apoptosis  - Calcium signal is a crucial factor that mediates transcription of PD-L1 and *regulation of calcium can be used as potential strategy for PD-L1 inhibition* - Dihydropyrimidine calcium channel blockers of which amlodipine is a congener can *inhibit transcription level of PD-L1*  - We have published our perspective on this topic , we got it published in *international journal of molecular and immunooncology* this…