Anemia is a common clinical finding in primary care, but distinguishing iron deficiency anemia (IDA) from anemia of chronic disease (ACD) requires a careful diagnostic approach. IDA typically presents with low serum ferritin and high total iron-binding capacity (TIBC), reflecting true iron depletion. In contrast, ACD is driven by inflammation-mediated iron sequestration and is characterized by normal to high ferritin, low TIBC, and low serum iron. The presence of chronic infection, autoimmune disease, or malignancy often points toward ACD.
Additional markers like CRP and soluble transferrin receptor levels can aid differentiation in complex cases. Misclassification can lead to inappropriate iron supplementation or delayed diagnosis of underlying pathology. Here is a quick question about anemia of chronic disease! Reference : Seminars Hematology ##Disclaimer## The content provided on…
