Domperidone is a peripheral dopamine antagonist ,benzamide derivative with antiemetic and gastric prokinetic properties. first discovered in 1974 and first marketed in 1979. Domperidone acts as peripherally selective antagonist of dopamine d2 and d3 receptors,this increases motality in upper git and lower esophageal sphinctor pressure and simultaneously blocks receptors at ctz.(chemo receotor zone) its does not crosses blood brain barier bbb.
Dopamine recetors first described in 1976 and these receptors distributed in cns and in extra cns places. Antipsychotic drugs acts mainly on CNS dopamine receptors and domperidone on peripheral d2 and d3 receptors. Peripheral receptors are d1 to d5,mainly distributed in d1 smooth muscles of all major blood vessels d2 and d3 in gastro intestinal tract d4 atria of heart d5 pulmonary artery Uses are: nausea and vomiting gastro paresis either diabetic…
