In patients undergoing percutaneous transluminal coronary angioplasty (PTCA) and percutaneous coronary intervention (PCI) require blood-thinning. Bivalirudin is one such thrombin inhibitor which is used. This article aims to provide a short summary of bivalirudin . Any patients with unstable angina who require PTCA also warrant blood thinning. Similarly, patients undergoing PCI also require blood thinning. Bivalirudin is one such drug which is used for blood thinning.
Bivalirudin is a specific and reversible direct thrombin inhibitor (DTI). It is a synthetic congener of naturally occurring hirudin. Bivalirudin is commonly used to overcome the limitations of indirect thrombin inhibitors such as heparin. It has an inhibiting action for both circulating and clot-bound thrombin. It also inhibits thrombin-mediated platelet activation and aggregation. Its quick activation, short half-life and…
