Have you considered botulinum toxin for patients with digital ischemia or ulcers that haven't responded to vasodilators or immunosuppressants? ##Reference## Zhu C, Peri K, Silotch C, et al. Botulinum Toxin for Refractory Digital Ischemia and Ulcers in Systemic Sclerosis: A Systematic Review and Meta-Analysis. JAMA Dermatol. 2026;162(1):47–54.## ##Disclaimer## The content provided on Docplexus is intended for educational purposes only.
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