An asymptomatic 40-year-old man was found to have a palpable right axillary lymph node. The node was thought to be infectious, but it did not resolve with antibiotic treatment and continued to enlarge. Excisional biopsy showed metastatic adenocarcinoma of unknown primary, positive for CK7; and negative for estrogen receptor (ER) and progesterone receptor (PR), CD20, prostate-specific antigen, ribosome recycling factor, prostatic acid phosphatase, and gross cystic disease fluid protein 15 (GCFDP-15).
was performed and a genomic profile of the tumor was ordered. A PALB2 truncating mutation was reported. *This case is from Docplexus editorial team for educative purpose only Source: Cancer Network