This article is written by Akshay Jain and Archana Singal. Corticosteroids (CS) are the steroidal compounds derived from the Adrenal cortex or prepared synthetically. Broadly, CS belong to three categories namely Glucocorticoids, Mineralocorticoids and Sex steroids. Natural glucocorticoids maintain blood sugar and assist the body to recover in times of stress. CS is available for topical, oral and injectable use.
Topical corticosteroids (TCS) are mainly Glucocorticoids. The first successful usage of TCS was of Hydrocortisone (compound F) in humans by Sulzberger and Witten in the year 1952. CS have anti-inflammatory, immunosuppressive and antiproliferative effects. In addition, TCS inhibit synthesis of both mucopolysaccharides and collagen in the dermis, leading to dermal atrophy. TCS are dispensed in various vehicles including creams, lotions, ointments, gels and foams; the ointment…
