Each country differs by its own ways and parameters if we take India:  Our climate Our Genetic makeup Our  lifestyle  Our Food habits  Our Skin Texture and Colour Our Height weights Our  Alcohol consumption ( liver induction etc )  Everything differs. Many side effects and benefits of various drugs and treatments are not seen in Indian population completely. Example : How does Salt restriction in Hypertensives suit in Indian summers? Every controversial topic should  be studied, pursued, thought, evaluated, observed, discussed personally and then doctors should come to conclusions.

Not just by blindly following biased, funded, changing every year International references. FDA approval, International references, International guidelines etc are they 100% correct? Can they be followed blindly without our personal study and evaluation?