Correlation Between Diabetes, DPP4 Inhibitors and ACE2 Inhibitors in COVID-19

Globally, diabetes has been reported as one of the major comorbid conditions affecting the treatment outlook in COVID-19 cases. Predictors of poor outcomes of COVID-19 include age, concomitant diseases like diabetes, cardiac insufficiency, and pulmonary disorders, and reduced immunity and high inflammatory responses. Hence, special norms or guidelines are required to manage COVID-19 in diabetic patients.

Diabetes and COVID-19 According to the Centers for Disease Control and Prevention (CDC), patients with diabetes and/or metabolic syndrome are nearly ten times more susceptible to developing severe COVID-19 and death. 1 Dysfunction of granulocytes, monocytes/macrophages, dendritic cells, natural killer cells, B cells, T cells, and cytokine signaling is observed in diabetic patients. 2,3 Individuals with diabetes-predisposing genes are at an increased risk of developing an impaired immune…