A 13-year-old girl with a 20-month history of type 1 diabetes mellitus presented with depressed areas of skin at the sites of insulin injection. The patient had been treated since diagnosis with injections of biphasic insulin into both thighs. The physical examination and axial magnetic resonance imaging of the right thigh showed a loss of the adipose tissue layer at the injection sites.
What could be the possible reason behind the loss of adipose tissue? *This case is from the Docplexus Editorial Team and is meant for educative purpose only.
