Diclofenac is considered as one of the few first line NSAIDs in the treatment of an array of acute and chronic painful and inflammatory conditions starting from arthritis to ankylosing spondylitis, tendinitis, and bursitis. It is available in almost every possible form such as oral, topical, injections etc. Aceclofenac, which is also a NSAID, used to treat almost similar symptoms to diclofenac said to have an equal efficacy but a greater tolerability than diclofenac. This article will review different studies comparing this two potent NSAIDs.
The anti-inflammatory activity of diclofenac and most of its other pharmacological effects are attributed to its inhibition of prostaglandin synthesis. Diclofenac is a potent inhibitor of cyclooxygenase in vitro and in vivo, thereby reducing the synthesis of prostaglandins, prostacyclin, and thromboxane products. On the other hand, aceclofenac is…
