Highlights Endometriosis affects nearly 15% of patients with infertility, requiring assisted reproduction treatment like in-vitro fertilization (IVF). Lower fertilization and pregnancy rates are observed in patients with endometriosis pursuing IVF. Long-term use of Gonadotropin-releasing hormone agonist (GnRHa) is associated with various hypo-estrogenic adverse effects. Dienogest (DNG), a selective progestin reduces the activity of endometriotic lesions and is a safe substitute for GnRHa pretreatment in endometriosis patients.
This Journal Watch discusses the study “Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial” from BMC Pregnancy and Childbirth. Authors : Eissa Khalifa, Hashem Mohammad, Ameer Abdullah, Mazen Abdel-Rasheed, Mohammed Khairy, and Mahmoud Hosni What was the need for the study? Lower fertilization and…
