In the United States, ECT used to help major depressive disorder, largely as a secondary treatment after one or more trials of psychotropic medications have failed. It is primary treatment provided symptoms demand urgent improvement. ECT is used more commonly in the US for Schizophrenia as medical treatment alone is not sufficient in treating subtypes of psychotic depression. Proposed Mechanisms: The exact mechanism is unclear.

But 4 theories are proposed as mentioned below: Monoamine neurotransmitter theory  Neuro endocrine theory T anticonvulsant theory Neurotropic theory  The monoamine theory suggests ECT works by by increasing Dopamine, Serotonin, & Adrenergic and possibly by GABA & glutamate, Neuro transmission. Neuroendrocrine thoery suggests release of hypothalamic or pituitary harmonies, including prolactin, TSH, adrenocorticotropic harmonies and endorphins. The release of…