EV is also an immune disease compromising a person’s immune function, making him/her more susceptible to HPV infection. Progressive development of hyper- or hypopigmented, flat, wart-like papules is observed along with seborrheic keratosis-like lesions, irregular reddish-brown plaques, and pityriasis versicolor-like macules on the trunk, neck, face, dorsal hands, and feet. This disease is also known as “Tree man syndrome,” as it causes bark-like growth in severe stages. HPV is contagious and can transmit through skin-to-skin contact.
Epidemiology The Genetic and Rare Diseases Information Center (GARD) literature reports about 501 patients worldwide , most of which are sporadic and a few are familial cases. About 7.5%, 61.5%, and 22% of cases are observed to be manifested during infancy, childhood, or puberty, respectively . HPV5 and HPV8 subtypes are found in 80% of cases, while 30–60%…
