Highlights · Although there are numerous new DED treatment options, HA eye drops act as an effective tear supplement for managing mild to severe DED. · Various modifications have been made to HA eye drops for improving their efficacy, including introducing different concentrations, combining them with carboxymethyl cellulose (CMC) or hydroxypropyl-guar (HPG), and adjusting their osmolarity.
A randomized multicenter clinical trial demonstrated that the sequential application of 0.3% and 0.15% unpreserved HA improved symptoms or signs of patients with moderate to severe DED.