A 57-year-old man presented with dyspnea and hemoptysis. He had a history of amyloid light-chain systemic amyloidosis with renal involvement and a remote history of pulmonary emboli. He was also currently taking lenalidomide. A ventilation-perfusion lung scan was in determinate for an acute pulmonary embolus.

Therefore, he was empirically anticoagulated with warfarin. Shortly after, he developed significant epistaxis, gingival bleeding, and large bilateral flank ecchymoses (figure). What is the cause of blue skin? *This case is from Docplexus Editorial Team for educative purpose only Source: The Lancet Click here for correct answer!