Dear Physicians, Long-term therapy often brings subtle complications needing vigilant recognition. Test your clinical acumen in identifying key nutrient deficiencies linked to chronic metformin use. ##Reference## De Jager J, et al.
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: follow-up of a randomized controlled trial. BMJ. 2023;382:12865.##