Mitochondria are dynamic organelles found within the cytoplasm of eukaryotic cells, which are responsible for the production of cellular energy through oxidative phosphorylation. Less attention has been paid to the fact that several disorders of the skin are linked to alterations of mitochondrial energy metabolism. Ten per cent of patients with primary mitochondrial disorders presents skin manifestations that can be categorized into hair abnormalities, rashes, pigmentation abnormalities and acrocyanosis.
There is continuing evidence supporting the proposal that mitochondrial dysfunction and oxidative stress are important contributing factors in the development of skin photoaging. Further skin-directed mitochondrial research is warranted to fully understand the impact of mitochondrial status and function in skin health. Emerging evidence suggests that mitochondria are vital regulators of…
