Spot the name of the signaling protein from the grid using the following hints! It is a family of key mediators of toll-like receptors (TLR). It operates at the nexus of multiple inflammatory pathways implicated in hematologic malignancies. In addition to inflammation, the signaling protein controls diverse other cellular processes like apoptosis and cellular differentiation. Click here to know the correct answer!
The correct answer is Interleukin 1 receptor-associated kinase (IRAK). Explanation: Several studies implicating IRAK signaling in hematologic malignancies and promising preliminary clinical trial data validate IRAK-targeted therapy as an exciting approach to hematologic malignancies. These targeted therapies have already matriculated to early-phase trials and are yielding promising preliminary results. Reference: Current Opinion in Hematology, 2022
