Recent studies indicate a link between obesity and asthma incidence. Depending on the data is clear that inflammatory mechanisms play a crucial role in determining the linkage of this phenomenon. Based on the studies, the present article outlines the underlying link between obesity and asthma. Obesity is accompanied by chronic low-grade inflammation that augments systemic complications. The obese asthmatic patients are less responsive to corticosteroids as they exhibit a different inflammatory phenotype.
Some epidemiological studies report that obesity is responsible for increasing the risk of asthma and implicate immunological mechanisms. Role of Adipokines Leptin It is secreted mostly by adipose tissue and the levels of this compound increase with obesity. Leptin receptors are expressed by human lung cells, epithelial cells, type II pneumocytes, and macrophages. Research studies…
