Tuberous sclerosis also known as bourneville disease is a familial disorder associated with variety of abnormalities involving Skin Eyes CNS  Tuberous sclerosis  are as follows Facial angiofibroma Ungal fibroma multiple Cortical tuber Subependymal nodules protruding into ventricle Subependymal nodule giant cell stroma Multiple retinal arstroma   ocular manifestations of Tuberous sclerosis  are as follows   Retinal arstromas Granulomas of disc Granuloma of retina Patch iris hypopigmentation Atypical iris coloboma Share your views.