Acid is continually produced in the body through the metabolic process. Despite this addition of acid to body, the pH is maintained within a narrow range of 7.35--7.45 Acidosis =Increased acid or decreased alkali Alkalosis =Increased alkali or decreased acid Metabolicdisorders = Primary change is in HCO 3 Respiratory disorders = Primary change is in PaCO 2 The pH is maintained by two major mechanisms namely Compensation & Correction Compensation = Alters the component not primarily responsible for abnormality. It tries to bring the values towards normal but never complete. Correction = pH is normalised by altering the component that is primarily responsible for the abnormality.
It may be acute or chronic. Immediate large-scale change in PH is prevented by buffers which include HCO3, Phosphates, and Protein buffers. Regulation of PH ultimately depends on lungs and the kidneys. Role…
