Oral propranolol is safe for the treatment of infantile hemangioma (IH), according to what is believed to be the largest systematic review on the topic. "Since 2008, we have many reports concerning the efficacy of propranolol, however a systematic review on safety was lacking....."In pediatrics we are very concerned by the safety of drugs, especially the drugs used in vulnerable populations such as infants less than one year of age"....propranolol can be used safely to treat complicated infantile haemangiomas, provided appropriate pre-treatment assessments to exclude patients with cardiologic contraindications; and appropriate monitoring to minimize serious side-effects, mainly bronchospasm and hypoglycemia, during treatment.
The most common propranolol-related events (sleep disorders, diarrhea, peripheral coldness, and agitation) are transient, manageable and not serious.... "oral…
