The objective of the study was to review the literature on root anatomy and canal configuration in permanent mandibular second molar based on Vertucci classification. Online electronic databases such as PubMed‑Medline, Embase, Scopus, and Cochrane Library were searched using appropriate keywords from the earliest available date till 10th February 2021 restriction on language. Additional sources such as Google Scholar, major journals, unpublished studies, conference proceedings, and cross‑references were explored.

Information curated for data extraction included methodology, population, sample size (number of teeth), number of root canals, and type of root canal configuration (RCC). Thirty‑seven articles were selected with a total of 12,393 permanent mandibular second molar teeth. In the mesial root, Type IV canal configuration with 37.3% was more frequent, having two canals with 70.4%.…