Highlights Sperm DNA fragmentation (SDF) has been associated with male infertility , especially idiopathic male infertility, suggesting that the causes of male factor infertility are likely complex. Sperm DNA integrity is a crucial indicator of sperm viability for a successful pregnancy. Sperm DNA damage testing is one of the specialized sperm function assay used to assess the paternal genome's quality. Antioxidant therapy helps maintain DNA integrity while improving important seminal parameters and baseline DNA damage.
This article provides a detailed understanding of the causes of SDF and how they relate to different cases of male infertility and treatment . Male Infertility & Sperm DNA About 15% of all couples worldwide experience infertility; male factor accounts for 50% of all cases . 1 Since sperm DNA makes up almost half of the embryonic genome, its integrity is crucial for…
