Drug Molecule Information Sumatriptan is indicated for the acute treatment of migraine with or without aura in adults. Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors. It causes vasoconstriction of cranial arteries and/or inhibition of neurogenic inflammatory processes in the CNS. A small but significant delay in gastric emptying also occurs. Indications and dosage Oral Migraine Adult: >18 yr: 50-100 mg repeated at 2-hr intervals if migraine recurs. Max: 300 mg/24 hr. Hepatic impairment: Max single dose: 50 mg.
Nasal Migraine Adult: 12-17 yr: 10 mg into 1 nostril, repeated at least 2 hr after the 1st dose if symptoms recur. Max: 20 mg/24 hr. >18 yr: 20 mg into 1 nostril, repeated at least 2 hr after the 1st dose if symptoms recur. Max: 40 mg/24 hr. Hepatic impairment: Dose reduction needed. Subcutaneous Migraine; Cluster headache Adult: >18 yr: 6 mg as a single…
