Diet + CBT in Endometriosis: A New RCT Approach Endometriosis , a chronic inflammatory and estrogen-dependent disorder affecting nearly 10% of reproductive-age women , continues to impose significant pain burden and reduced quality of life despite standard hormonal and surgical treatments. Recognizing the growing interest in self-management strategies, this randomized controlled trial protocol ( PEARL study ) investigates the effectiveness of an anti-inflammatory diet intervention ( AIDI ) and cognitive behavioural therapy ( CBT ), individually and in combination, in improving pain and health-related quality of life (HRQoL).
In this five-arm factorial RCT, 250 premenopausal women (200 with endometriosis and 50 healthy controls) will be followed over a 13-week intervention period, with participants randomized into standard care alone or with AIDI, CBT, or both. The primary outcome is…
