Now, people infected with HIV can alter their chances of death from tuberculosis(TB) by receiving prophylaxis, even while they are on antiretroviral therapy (ART). TB is the leading infectious cause of death in people with HIV. A recent long-term follow-up data from the French Agency for Research on AIDS and Viral Hepatitis (ANRS) TEMPRANO trial reported that the use of isoniazid preventive therapy (IPT) can decrease TB morbidity and mortality in HIV patients on ART. The value of IPT in preventing TB in HIV patients was shown by the study since long.
This finding made the World Health Organization (WHO) to issue recommendations in 1993, that people living with HIV in countries where TB is widespread should take isoniazid for six months. However, these recommendations have been rarely applied. The current TEMPRANO trial re-evaluated the importance of IPT in the age of ART. Study design…
