OBJECTIVE: Does Vit D have the potential to prevent T2DM? STUDY: D2d Study published in the 8 Aug 2019 issue of NEJM (online 7th Jun 2019} 2,423 patients of pre-diabetes with 2 of the 3 prediabetic criteria (no diagnostic criteria of diabetes were present) ... 1,211 = Vit D group, 1212 = placebo group. Primary Outcome : Time-to-event analysis for new-onset diabetes. Event-driven model with target to 508 events RESULTS : Median Follow-up = 2.5 years At 2 years, Vit D levels in Vit D group = from 27.7 ng/mL to 54.3 ng/mL as compared to the Placebo group = from 28.2 ng/mL to 28.8 ng/mL Pr.
outcome Event Rates : Vit D Group = 293 (9.39 events/100 person-yrs) vs Placebo group = 323 (10.66 events/100 person-yrs) ... HR = 0.88 (95% CI, 0.75 to 1.04; P = 0.12 ). CONCLUSION: Though Vit D supplementation restored Vit D levels, it did not prevent T2DM. MY COMMENTS: I am happy that,…
