Highlights ·        Healthy and functioning meibomian glands play a crucial role in ocular surface health.1 ·        Meibomian gland dysfunction (MGD), a complex multifactorial disorder, is the most common cause of dry eyes.2 ·        Besides two dry eye disease (DED) subtypes, evaporative dry eye (EDE) is the most frequent. EDE is characterized by a vicious cycle of impaired tear film quality, primarily due to MGD.1 ·        This infographic highlights the vicious circle of DED, various underlying mechanisms for MGD development, its relationship with DED, and efficient treatment approaches to manage MGD and DED.