Postpartum bleeding is a leading cause of maternal deaths worldwide. It is indicated in the preliminary studies that the early administration of tranexamic acid reduced deaths due to bleeding in trauma patients. The clinical trial, WOMEN assessed the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with postpartum hemorrhage complications. Globally around 100,000 women die every year due to postpartum hemorrhage. Postpartum hemorrhage is defined as a blood loss of more than 500ml within 24h of giving birth.
Most of such deaths occur in low or middle-income countries. Early activation of fibrinolysis is common after trauma (or postpartum) and hence associated with bleeding and mortality. Tranexamic acid inhibits the enzymatic breakdown of fibrinogen and fibrin by plasmin. Clinical trials have indicated that the tranexamic…
