The US FDA has approved adapalene 0.1%/benzoyl peroxide 2.5% gel (Differin Epiduo Acne Gel), a fixed-dose combination acne treatment, for over-the-counter use in individuals aged 12 years and older. While this combination of a retinoid and benzoyl peroxide will be available OTC in the US, it will remain a prescription-only product outside the US. The gel is indicated to help clear existing acne and prevent new breakouts.
Clinical Evidence Clinical trials demonstrated that adapalene/benzoyl peroxide gel was more effective than adapalene alone, benzoyl peroxide alone, and vehicle gel in reducing inflammatory, non-inflammatory, and total acne lesions, as well as improving Investigator Global Assessment (IGA) success rates. Improvements in lesion counts were observed as early as week 1. The combination also showed antimicrobial activity from day 1 and achieved a 70.3% reduction in…
