Prolonged glucocorticoid therapy can suppress the hypothalamic-pituitary-adrenal (HPA) axis. Appropriate timing and gradual dose reduction are important to minimize glucocorticoid withdrawal symptoms and manage the risk of adrenal insufficiency. (Scroll down to answer the question) Reference:  The Journal of clinical endocrinology and metabolism ##Disclaimer## The content provided on Docplexus is intended for educational purposes only. While we strive to ensure its accuracy, we make no explicit or implied warranties about the information's suitability, reliability, or adequacy, including data visualization elements and graphics.

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