A 13-year-old girl with a 20-month history of type 1 diabetes mellitus. She presented depressed areas of the skin at the site insulin injection (Panel A, arrows). The patient had been injecting biphasic insulin lispro into both thighs. MRI of right thigh showed a loss of the adipose tissue layer at the injection site (Panel B). This was considered as a case of lipoatrophy. Which possible mechanisms induce lipoatrophy?
How should this patient be managed? Reference : NEJM ##Disclaimer## The content provided on Docplexus is intended for educational purposes only. While we strive to ensure its accuracy, we make no warranties, explicit or implied, about the suitability, reliability, or adequacy of the information, including data visualization elements and graphics. We do not endorse any medical treatment, product, ideas or service, including the content from our industry partners. We do not…
