A 36-year-old man with Tangier disease (a rare autosomal disorder) came with his wife to the hospital regarding infertility issue. The man was diagnosed with oligoasthenoteratozoospermia. The patient was negative to frequent bacterial and viral test; CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene mutations; Yq microdeletion. Hormonal analyses showed low total testosterone and significant decline in inhibin B. Is there any association between Tangier disease and male infertility in this case? *This case is for Docplexus editorial team for educative purpose only Source: Stocchi L, Giardina E, Varriale L, Sechi A, Vagnini A, Parri G, Valentini M, Capalbo M.
Can Tangier disease cause male infertility? A case report and an overview on genetic causes of male infertility and hormonal axis involved. Mol Genet Metab. 2018 Jan;123(1):43-49. The correct answer posted in the…
